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Na revisão sistemática e meta-análise E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis (Kalkhoran e Glantz, 2016), publicada na revista científica The Lancet Respiratory Medicine, pessoas que tentaram parar de fumar cigarro convencional utilizando cigarros eletrônicos tiveram 28% menos chance de sucesso do que os que não utilizaram esses dispositivos eletrônicos para fumar (DEFs)